When blood is flowing out of the left ventricle, the bicuspid valve is __________ and the aortic semilunar valve is __________.

During the process of blood flowing out of the left ventricle, the bicuspid valve, also known as the mitral valve, is closed. This closure is crucial because it prevents the backflow of blood into the left atrium as the ventricle contracts and forces blood out into the aorta.

Simultaneously, the aortic semilunar valve is open, allowing the blood to flow from the left ventricle into the aorta, and subsequently to the rest of the body. This sequence is vital for proper circulation, ensuring that oxygen-rich blood is effectively delivered to the systemic circulation while preventing any regurgitation of blood into the heart during ventricular contraction.

Thus, the correct configuration of the valves during this phase of the cardiac cycle is that the bicuspid valve is closed, and the aortic semilunar valve is open, which aligns perfectly with the chosen answer.